Efficacy of live oral rotavirus vaccines

Inhibitory effect of breast milk on infectivity of live oral rotavirus vaccines.

BACKGROUND Live oral rotavirus vaccines have been less immunogenic and efficacious among children in poor developing countries compared with middle income and industrialized countries for reasons that are not yet completely understood. We assessed whether the neutralizing activity of breast milk could lower the titer of vaccine virus and explain this difference in vitro. METHODS Breast milk s...

Annex 3 GUIDELINES TO ASSURE THE QUALITY, SAFETY AND EFFICACY OF LIVE ATTENUATED ROTAVIRUS VACCINES

PART A.GUIDELINES ON MANUFACTURING A.1. Definitions ...................................................................... A.2. General manufacturing recommendations .................................. A.3. Control of source materials ................................................... A.4. Control of vaccine production ................................................ A.5. Filling and containers...

RotaTeq, INN-Rotavirus vaccine, live, oral

Live Attenuated Vaccines: Influenza, Rotavirus and Varicella Zoster Virus

Since vaccinia virus was first used to protect against smallpox in the eighteenth century, live attenuated vaccines have proved to be highly effective in reducing the morbidity and mortality caused by many human viral pathogens. Contemporary live viral vaccines are designed using several different strategies to achieve attenuation. These basic principles and approaches are illustrated by vaccin...

Intussusception, rotavirus, and oral vaccines: summary of a workshop.

Rotavirus gastroenteritis continues to cause substantial morbidity and mortality worldwide, despite widespread breastfeeding and use of oral rehydration therapy. This burden of disease indicates that an effective, safe rotavirus vaccine is needed, and in 1998 the first rhesus-human reassortant rotavirus tetravalent vaccine, Rotashield, was licensed in the United States. However, the recommendat...